Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate CAS NO.139481-44-0

Manufacture of Candesartan cilexetil intermediates(methyl ester C6): TLS pharmaceutical Co., LTD is located at the foot of the World Tourism At…

Manufacture of Candesartan cilexetil intermediates(methyl ester C6):
TLS pharmaceutical Co., LTD is located at the foot of the World Tourism Attractions Emeishan, which is in the town of Shengli . It situated at the foot of a hill and beside a stream , the environment is very beautiful . It posses a registered capital reaching 20 million yuan , covers an area of 20,000 square meters , construction area of 18,000 square meters and the total assets amounts to 60 million yuan.After the founding of the company,it depends on the support of government and the techniques of academies in Beijing,Shenzhen and Sichuan province.TLS aims at the demand of the standard market of bulk drugs at home and abroad , owns many workshops certified by GMP and many pilot workshops for medicinal intermediates and it is equipped with improved public facilities and assistant facilities with standard qulity management system (QMS) and advanced Quality Control (QC) methods. More important , it cooperates with famous pharmaceutical companies at home and abroad , and provides excellent quality bulk drugs , key intermediates and pilot production technology for them.

The company's main products: candesartan cilexetil ( CAS No. 145040-37-5 ) and intermediates: acid methyl ester compounds ( CAS No. 139481-44-0 ); carboxylic acid ethyl ester compounds ( CAS No.139481-41-7 ); cyclic compounds ( CAS No.139481-69-9 ); candesartan ( CAS No.139481-59-7 ).

Propertise of Candesartan cilexetil intermediates(methyl ester C6):
(1)ACD/LogP:5.761; (2)# of Rule of 5 Violations:1; (3)ACD/LogD (pH 5.5):5.74; (4)ACD/LogD (pH 7.4): 5.76; (5)ACD/BCF (pH 5.5):13494.00; (6)ACD/BCF (pH 7.4):14066.64; (7)ACD/KOC (pH 5.5):31098.96; (8)ACD/KOC (pH 7.4): 32418.70; (9)#H bond acceptors:6; (10)#H bond donors:0; (11)#Freely Rotating Bonds:7; (12)Index of Refraction: 1.619; (13)Molar Refractivity:119.753 cm³; (14)Molar Volume:341.495 cm³; (15)Polarizability:47.474 10-24cm³; (16)Surface Tension:46.2249984741211 dyne/cm; (17)Density:1.205 g/cm³; (18)Flash Point:335.064 °C; (19)Enthalpy of Vaporization:93.245 kJ/mol; (20)Boiling Point:630.416 °C at 760 mmHg; (21)Vapour Pressure:0 mmHg at 25°C.

Specification of Candesartan cilexetil intermediates(methyl ester C6):